This paper analyses the socio-economic determinants of hospitalizations and death rates related to Covid-19 on the one hand, and the excess mortality observed this year compared to previous ones, on the other. It proposes a territorial approach to these questions thanks to the use of data calculated at the French departments level. The exploratory spatial analysis carried out reveals the heterogeneity and spatial autocorrelation of the disease and its consequences. The use of spatial econometric models, then, allows us to highlight the influence of demographic density, social inequalities, part of blue-collars in the active population and emergency services on the studied phenomena.