This article examines the spatial distribution of jobs in the Paris Region. Going beyond the standard analysis often centered on economic sectors, it focuses instead on the functions achieved by the jobs. We rely on exploratory spatial data analysis (ESDA) and segregation indicators. We bring to light the hyper-mono-centric structure of the job distribution in the Paris Region in 2007 and, further, show its asymmetric and segregated nature. These results call for additional work on the link between the spatial differentiation and functional segregation of the jobs, and a city’s wealth, productivity and status in the globalized economy. They also challenge the role that the functional hyper-centrality could play in the competition among global metropolises.